57th. Annual National Conference of Indian Society of Anaestbesiologists 2009 Chennai, India 26 - 30 Dis ember 2009.

Loading...
Thumbnail Image
Date
2009
Authors
Gnandev, Pbutane
Journal Title
Journal ISSN
Volume Title
Publisher
Pusat Pengajian Sains Perubatan
Abstract
Background end goals of study. to evaluate the eflicacy,safety,tolerability & side effect between of pregabalin, gabapentin and topiramate in chronic pain management Methods: Prospective, double blind,randomized controlled trial of 12 weeks duration comparing pregabalin, gabapentin & topiramate. Study was conducted on patient with chronic pain clinic at LLRH, Kanpur. Participants were 120 patients with chronic pain. Tha primary outcome was difference between pregabalin, gabapentine & topiramate in chronic pain, as measured by the mean VAS score computed over weekly of each treatment period.Secondary outcomes were changes in mood, quality of life & psychomotor functions.Side effects were measured by questionnaire. Patient received a maximum dally dose of 600 mg gabapentine or 400 mg pregabalin or 1 00 mg topiramate along with 300 mg aceclofenac Results: Mean baselineVAS was 69.6 mm (29.4-95.2) on a scale of 0-100mm.120 patients were included in the available case analysis & 30 patients in the per protocol analysis. The mean score was 6mm longer for gabapentine than for pregabalin & topiramate in the available case analysis & 5.6 mm in the per protocol analysis. Cone/us/on: Gabapentine provided better pain relief than the pregabalin & topiramate & had slightly fewer side effects, well tolerable, although no major adverse events occur for either drug.
Description
Keywords
Citation