Zinc(II) Ferrocenylthiosemicarbazone Complexes : Structure, Electrochemistry, DNA Binding And Nuclease Activity
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Date
2011-08
Authors
Rajamuthy, Vikneswaran
Journal Title
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Publisher
Universiti Sains Malaysia
Abstract
Four zinc complexes of the formulae Zn{(η5-C5H5)Fe(η5-C5H4)C(H)=NN=C(S)NH2}2 (V), Zn{(η5-C5H5)Fe(η5-C5H4)C(H)=NN=C(S)N(H) CH3}2∙CH3OH (VI), Zn{(η5-C5H5)Fe(η5-C5H4)C(H)=NN=C(S)N(H)C2H5}2 (VII), Zn{(η5-C5H5)Fe(η5-C5H4)C(H)=NN=C(S)N(H)C6H5}2∙H2O (VIII) have been synthesised and characterised. The structures of these complexes have been established by a single-crystal X-ray diffraction analysis. The coordination geometries of the zinc centres are identical, showing a distorted tetrahedral coordination. The complexes are redox active, giving a reversible cyclic voltammetric response of the Fe(III) − Fe(II) couple near 0.5 V vs. Ag/AgCl. The binding constants, Kb, of the complexes for binding with CT DNA are in the range of 7.0 × 102 to 4.8 × 103 M-1. The complexes do not intercalate into the nucleobases of CT DNA as evident from viscosity measurements. They exhibit efficient nuclease activity in the absence of an activating agent by cleaving supercoiled DNA into nicked and linear forms of DNA at low concentrations.
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Keywords
Zinc(II) ferrocenylthiosemicarbazone complexes , structure, electrochemistry, DNA binding and nuclease activity