Zinc(II) Ferrocenylthiosemicarbazone Complexes : Structure, Electrochemistry, DNA Binding And Nuclease Activity

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dc.contributor.authorRajamuthy, Vikneswaran
dc.date.accessioned2018-12-10T06:53:07Z
dc.date.available2018-12-10T06:53:07Z
dc.date.issued2011-08
dc.description.abstractFour zinc complexes of the formulae Zn{(η5-C5H5)Fe(η5-C5H4)C(H)=NN=C(S)NH2}2 (V), Zn{(η5-C5H5)Fe(η5-C5H4)C(H)=NN=C(S)N(H) CH3}2∙CH3OH (VI), Zn{(η5-C5H5)Fe(η5-C5H4)C(H)=NN=C(S)N(H)C2H5}2 (VII), Zn{(η5-C5H5)Fe(η5-C5H4)C(H)=NN=C(S)N(H)C6H5}2∙H2O (VIII) have been synthesised and characterised. The structures of these complexes have been established by a single-crystal X-ray diffraction analysis. The coordination geometries of the zinc centres are identical, showing a distorted tetrahedral coordination. The complexes are redox active, giving a reversible cyclic voltammetric response of the Fe(III) − Fe(II) couple near 0.5 V vs. Ag/AgCl. The binding constants, Kb, of the complexes for binding with CT DNA are in the range of 7.0 × 102 to 4.8 × 103 M-1. The complexes do not intercalate into the nucleobases of CT DNA as evident from viscosity measurements. They exhibit efficient nuclease activity in the absence of an activating agent by cleaving supercoiled DNA into nicked and linear forms of DNA at low concentrations.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/7245
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectZinc(II) ferrocenylthiosemicarbazone complexesen_US
dc.subjectstructure, electrochemistry, DNA binding and nuclease activityen_US
dc.titleZinc(II) Ferrocenylthiosemicarbazone Complexes : Structure, Electrochemistry, DNA Binding And Nuclease Activityen_US
dc.typeThesisen_US
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