Antioxidant, anti-angiogenic and antiinflammatory activities of standardized Gynura Segetum leaf extracts
| dc.contributor.author | Seow, Lay Jing | |
| dc.date.accessioned | 2015-05-27T08:19:57Z | |
| dc.date.available | 2015-05-27T08:19:57Z | |
| dc.date.issued | 2014-09 | |
| dc.description.abstract | Gynura segetum (daun dewa in Malay) is a herb, reputed of value among others for treatment of inflammation and cancer. In the present study, the anti-inflammatory activity of the standardized leaf extracts of Gynura segetum were investigated as well as its possible relation to antioxidant, anti-angiogenic and cytotoxic activities. The ethyl acetate fraction showed the strongest antioxidant activity based on DPPH scavenging activity and beta carotene bleaching capacity assays and directly related to its total phenolic and flavonoid contents. The methanol extract was the most active in inhibiting the blood vessels growth in chick embryo chorioallantoic membrane (CAM) assay and rat aortic ring assay. It shows it has anti-angiogenic activity. It is non-cytotoxic and suppression of vascular endothelial growth factor (VEGF) activity is one of the anti-angiogenic mechanisms of action. The methanol extract possesses anti-inflammatory activity as it inhibited SDS-induced irritation in hen’s egg chorioallantoic membrane (HET-CAM) test and cotton pellet-induced granuloma formation in rat. Its anti-inflammatory activity is mediated through the inhibition of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1) and cycloxygenase-2 (COX-2) enzyme activities. Taken together, the present study suggests that Gynura segetum’s leaf is a natural source of antioxidants and possesses anti-angiogenic activity which may explain its chronic anti-inflammatory activity and anti-cancer potential. | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/778 | |
| dc.subject | Gynura Segetum Leaf | en_US |
| dc.title | Antioxidant, anti-angiogenic and antiinflammatory activities of standardized Gynura Segetum leaf extracts | en_US |
| dc.type | Thesis | en_US |
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