Studies On Standardization Of Ficus Deltoidea Jack And Orthosiphon Stamineus Benth. Leaf Extracts For Selected Anti-Hypertensive And Anti-Angiogenic Effects

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dc.contributor.authorDarestani, Armaghan Shafaei
dc.date.accessioned2019-06-17T07:16:53Z
dc.date.available2019-06-17T07:16:53Z
dc.date.issued2012-06
dc.description.abstractFicus deltoidea (FD) and Orthosiphon stamineus (OS) were used traditionally for treatment of a wide range of diseases related to diabetes, hypertension, inflammation and angiogenesis related diseases in Malaysia. Therefore, this study was aimed to generate data and evidence about standardization of two medicinal plants namely Ficus deltoidea (FD) and Orthosiphon stamineus (OS) for antihypertensive and anti-angiogenesic effects, since there is lack of sufficient scientific data in this regard. In this study, gravimetric analysis and microbial limit test (MLT) were applied on the dried powder of the leaves to examine the quality and safety of the raw material. Both FD and OS leaves were found to be qualified in terms of physicochemical properties as well as microbial contamination. Preliminary phytochemical screening on methanol and water extracts of FD and OS leaves showed the presence of phenolics, amino acids, flavonoids, terpenoids and saponins in FD and OS extracts. OS extracts also showed the presence of sterols. The chemical profile involving qualitative analysis by spectroscopic (UV, IR, NIR) and chromatographic techniques (HPTLC and GC-MS) and quantitative analysis by chromatographic techniques (HPTLC and HPLC) were carried out for standardization. Vitexin, isovitexin, L-citrulline, L-arginine and ursolic acid were used as markers for the analytical study of FD while, rosmarininc acid, 3-hydroxy- 5,6,7,4-methoxyflavone, sinensetin, eupatorin, oleanolic acid and ursolic acid were selected as markers for OS based on their medicinal values and their quantifiable levels.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/8303
dc.language.isoenen_US
dc.publisherUniversiti Sains Malaysiaen_US
dc.subjectStandardization of ficus deltoidea jack and orthosiphon stamineus benthen_US
dc.subjectfor selected anti-hypertensive and anti-angiogenic effectsen_US
dc.titleStudies On Standardization Of Ficus Deltoidea Jack And Orthosiphon Stamineus Benth. Leaf Extracts For Selected Anti-Hypertensive And Anti-Angiogenic Effectsen_US
dc.typeThesisen_US
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