The Effects of Various Surfactants and Penetrants on the Percutendous Absorption of Dermatological Products
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Date
1981-02
Authors
YUSOFF, ABDUL AZIZ
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Abstract
In vitro release of salicylic acid from oint~ent
bases \';a3 inVC3tie3. ted I)":; a di ffus:-:;ion tec hnique er.r9loying
Ghicken porch as a Skin model. The ointmant bases
used were TIoolfat (anhydrous), ~hite soft paraffin,
emulsion ~ type, and )clyethylene Glycol. 10 percent
of salicylic acid waa incorporat~d into each of the
ointments prc]ared. T~o surfactants sodium lauryl
sulphate and dioctyl sodium sulfosuccinate and two penetrants
_ cholesterol and '~imethylsulfo~ide (DMSO)
were used to study their effec~s on the release pattern
of salic:rlic acid from the ointments. 10 ~e!ยท:;cr:.t of
each ',vere incor)ora ::2(~ into the oint:.lsnts.
soc.iu:!l lauryl sulphate ','Tas found to in::r r:3se the
release 0f salicylic acid from e~ul~!0n - ty~e oint-
T:1ent ba.-:;e. Dioc tyl sodiUl:l sulfosuccina te and Cholestarol
~ere found to increase the release from emulsion
_ type and polyethylene Sly~ol bases. ~hilst
DM30 facilitated the relca~c rr0~ e~ulsion - ty~e and
~hitc soft Dara:rin oases.
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Keywords
The Effects of Various Surfactants and Penetrants on the Percutendous Absorption , of Dermatological Products