Effects of royal jelly on biochemical and reproductive parameters in hyperandrogenised female rats
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Date
2018-04
Authors
Hamid, Norhamidar Ab
Journal Title
Journal ISSN
Volume Title
Publisher
Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
Abstract
histological results showed the numbers of primary and cystic follicles were
significantly higher while numbers of secondary follicle and corpora luteum were
significantly lower in T group compared to control group. In addition, the numbers of
primary and cystic follicles were significantly lower and numbers of secondary
follicle and corpora luteum were significantly higher in T+200RJ compared to T,
T+100RJ and T+400RJ groups but not significantly different from control group.
Malondialdehyde (MDA) and glutathione peroxidase (GPx) activities were
significantly higher while total antioxidant capacity (TAC) level was significantly
lower in T group compared to control group. However, in T+200RJ group, MDA
level and GPx activity were significantly lower while TAC level was significantly
higher compared to T group. These findings might suggest that RJ at 200 mg/kg/day
for 4 weeks improves reproductive hormone levels, oestrus cycle regularity, ovarian
histology and ovarian oxidant-antioxidant status in hyperandrogenised immature rats
as PCOS rat model. This effect could be attributed partly to the combined effects of
its phytochemical compounds that have oestrogenic and antioxidant properties. In
conclusion, RJ at the dose of 200 mg/kg/day significantly improves biochemical and
reproductive changes in hyperandrogenised female rats which need further study to
evaluate its exact mechanism of action.
Description
Keywords
Apitherapy , Methods