Effects of royal jelly on biochemical and reproductive parameters in hyperandrogenised female rats

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dc.contributor.authorHamid, Norhamidar Ab
dc.date.accessioned2020-08-26T01:19:07Z
dc.date.available2020-08-26T01:19:07Z
dc.date.issued2018-04
dc.description.abstracthistological results showed the numbers of primary and cystic follicles were significantly higher while numbers of secondary follicle and corpora luteum were significantly lower in T group compared to control group. In addition, the numbers of primary and cystic follicles were significantly lower and numbers of secondary follicle and corpora luteum were significantly higher in T+200RJ compared to T, T+100RJ and T+400RJ groups but not significantly different from control group. Malondialdehyde (MDA) and glutathione peroxidase (GPx) activities were significantly higher while total antioxidant capacity (TAC) level was significantly lower in T group compared to control group. However, in T+200RJ group, MDA level and GPx activity were significantly lower while TAC level was significantly higher compared to T group. These findings might suggest that RJ at 200 mg/kg/day for 4 weeks improves reproductive hormone levels, oestrus cycle regularity, ovarian histology and ovarian oxidant-antioxidant status in hyperandrogenised immature rats as PCOS rat model. This effect could be attributed partly to the combined effects of its phytochemical compounds that have oestrogenic and antioxidant properties. In conclusion, RJ at the dose of 200 mg/kg/day significantly improves biochemical and reproductive changes in hyperandrogenised female rats which need further study to evaluate its exact mechanism of action.en_US
dc.identifier.urihttp://hdl.handle.net/123456789/9918
dc.language.isoenen_US
dc.publisherPusat Pengajian Sains Perubatan, Universiti Sains Malaysiaen_US
dc.subjectApitherapyen_US
dc.subjectMethodsen_US
dc.titleEffects of royal jelly on biochemical and reproductive parameters in hyperandrogenised female ratsen_US
dc.typeThesisen_US
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