Pusat Pengajian Sains Farmasi - Tesis

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Browsing Pusat Pengajian Sains Farmasi - Tesis by Author "Furqan Faisal, Sarah"

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    In Vitro Anti Cancer Properties Of Thiadiazole Coumarin Derivatives Against Colon Cancer
    (2019-05)
    Furqan Faisal, Sarah
    Thiadiazole coumarin derivatives have been shown to be promising anti-cancer agents. In this study, five different thiadoazole coumarin derivatives (TCDs) were studied for their anticancer activity towards colorectal, breast and lung carcinoma. The TCDs {(OCH3-TC 1), (H3CO-TC 2), (H3CO-TC 3), (Br-TC 4), & (OH-TC)} are different in their structures. The compounds were tested for two important pathways of carcinogenesis namely angiogenesis and apoptosis. Angiogenesis is a process of new blood vessel development which is crucial for neoplastic tissues to obtain nourishment for their growth and metastasis.