Institut Perubatan & Pergigian Termaju - Tesis

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Browsing Institut Perubatan & Pergigian Termaju - Tesis by Subject "Acute transfusion reaction"

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    Haemovigilance Study Of Acute Transfusion Reactions At Hospital Sultanан Ваніyah
    (2020-10)
    Che Ros, Firdaus
    Introduction: Acute transfusion reactions (ATRs) are commonly reported in clinical transfusion practice, and they may result in significant morbidity and mortality. Haemovigilance system plays a major role in the monitoring of ATRs for prevention, as well to promote patient care and safety. This study aims to explore the characteristics and associated factors of ATRs at Hospital Sultanah Bahiyah, Kedah, Malaysia. Methods: This was a retrospective study using records from haemovigilance forms of reported transfusion reactions, E-Delphyn (blood bank system) and E-His (hospital information system). A total of 118 cases of ATRs from January 1st 2015, until December 31st 2017, were selected and analysed. For each case, a control was selected from a patient who did not develop ATR. Results: A total of 122,215 units of whole blood and blood component transfusions were performed and 415 ATRs were reported. The prevalence of ATR was 0.34% or one in 294 units transfused. The most common ATR is allergic reactions with 62 cases (52.5%), followed by febrile non-haemolytic transfusion reactions with 45 cases (38.1%), transfusion-associated circulatory overload with four cases (3.4%), and transfusion-associated dyspnoea with four cases (3.4%). Allergic reaction was significantly associated with female patients (p = 0.038) and the paediatrics age group (p = 0.038). There was a significant association between febrile non-haemolytic transfusion reaction and red blood cells (RBCs) stored >14 days (p = 0.002). Conclusion: The prevalence of ATRs at Hospital Sultanah Bahiyah was low and are associated with female patients, paediatric age group, and RBC's storage duration.